The FOXP2 gene as illustrated by Simon Fisher (Oriel College, Oxford), the investigator who first isolated the FOXP2 gene.
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A letter to the current issue of Nature has caused a stir among those interested in the evolution of language. It looks at the FOXP2 gene in more detail than any paper has ever done before. It also inspires at least as many questions as it answers, but now at least we have better questions. Also it has dealt yet another blow to the theory that language depends on distinct cognitive modules that permit internal thought and that later interface with motor modules (vocalizing or signing) for “externalizing” what you are thinking. If anything is becoming apparent from FOXP2, it is that language and motor activities are deeply entangled. It also provides more reason to doubt the original recent date ascribed to the gene's mutations.
The letter, titled, “Human-specific transcriptional regulation of C[entral] N[ervous] S[ystem] development genes by FOXP2,” was written by a large team represented by Genevieve Konopka and Daniel Geschwind (abstract here). The journal also had a summary article on the study, “The Importance of Being Human,” by Martin H. Dominguez and Pasko Rakic (abstract here).
The story so far: The FOXP2 gene is a highly stable gene, changing very little over millions of years, but it has changed twice since the last common ancestor with chimpanzees and bonobos, and it turns out to be important to the proper development of language. It cannot be directly responsible for speech, however, because it works by regulating the activity of other genes. (See: The Human FOXP2 Gene) The gene’s role in vocalization has been strengthened by evidence that FOXP2 is crucial in songbirds for enabling young birds to learn how to imitate the songs of their elders, (see: Birds Also Use FOXP2) and making echolocation sounds in bats (see: The Latest on the FOXP2 Gene). A year ago British researchers identified a “downstream” gene (CNTNAP2) regulated by FOXP2. Their report ended by saying that their work was a first step in understanding molecular networks affecting language. (See: A Second Gene Supports Language). Now it is time for another step.
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